WordPress 2.0.6 was released today. This is a critical security release (There are at least two security flaws that I know of that were fixed in this version). I went ahead and upgraded all of our blogs successfully.
If you manage more than, say, 10 blogs then perhaps Brian Layman’s script will be useful for you. As I noted in his comments, I do something similar but in a different way. It took me 4 minutes and 15 seconds to upgrade all 181 blogs currently active or being prepped in our network.